Omeprazole may cause a serious type of allergic reaction when used in patients with conditions treated with antibiotics. Genetic screening revealed that the patient poorly metabolized omeprazole.  Some people have experienced reactions to omeprazole that closely mimic the symptoms of common allergy attacks such as skin rash, hives, and feelings of tightness in the chest. Though unusual, moderate side effects of omeprazole have been reported by patients as well. Prilosec (omeprazole) is a proton pump inhibitor (PPI) that is used to treat the symptoms of ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Is it normal to have a reaction like this with Omeprazole. Photosensitivity reaction is found among people who take Omeprazole, especially for people who are female, 60+ old, have been taking the drug for < 1 month. Summary: Allergies is reported only by a few people who take Omeprazole. Stomach pain is a possible side effect of omeprazole. Allergic reaction to Omeprazole? There is no good way to know ahead of time if a person is going to have a reaction. Lvl2. Omeprazole is a common drug that some people take to treat heartburn, or acid reflux. By Tuesday my torso was covered in little red spots with some slight itching. The phase IV clinical study is created by eHealthMe based on reports of 289,144 people who have side effects when taking Omeprazole from the FDA, and is updated regularly. Pretty stressed about it. The phase IV clinical study is created by eHealthMe based on reports of 289,144 people who have side effects while taking Omeprazole from the FDA, and is updated regularly. However, if a reaction … Omeprazole works by blocking gastric acid secretion in your stomach which reduces heartburn, ... you should alert your doctor right away as this may indicate an allergic reaction … A number of adverse reactions caused by omeprazole have been reported, including allergic reactions, tachycardia, alimentary tract hemorrhage, liver damage, leucopenia, mental disorders and joint pain (7–18). The presence of cross-reactivity between different members of the group is not clear. Clinical symptoms appeared immediately in 8 patients and after … I was put on Omeprazole last week (Thursday). IV Prednisone and Piriton. Oral challenges using the culprit PPI resulted in symptoms of an allergic reaction when the skin test was positive, and there was over a 90% correlation between the skin test and the oral challenge. I took it for just under 2 weeks and on Friday had a terrible allergic rash with welts and hives everywhere. Common side effects of Prilosec include diarrhea, nausea, vomiting, headaches, rash, dizziness, nervousness, abnormal heartbeats, muscle pain, weakness, and infrequently, leg cramps and water retention. Had swelling lips and decided to go to A&E. The experimental skin tests appeared to be helpful in identifying the cause of their allergic reactions, especially when the PPI was the cause. Although rare, anaphylactic reactions induced by proton pump inhibitors have been reported. Therefore, severe adverse reactions (allergic shock, rash and diarrhea) experienced by the patient were caused by the accumulation of omeprazole metabolites resulting from its slow metabolism in vivo. Call your doctor right away if you or your child has itching, trouble breathing or swallowing, or any swelling of your hands, face, or mouth. Yes: Theoretically, a person could have an allergic reaction to any medication including omeprazole. In general Omeprazole and other ppi drugs are well tolerated. 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